How Ketamine Therapy is Saving Lives at Serenity

By: Tanner Manwaring, DNP

4/23/2025

If you're living with depression, PTSD, or addiction, you might feel like you've tried everything and nothing works. Chances are you’ve cycled through medications, endured side effects, and spent years in therapy or treatment centers with minimal relief. The weight of these conditions can be exhausting, and for many people, the road to recovery feels like a dead end. But what if there was something different? What if there was something that worked faster, reached deeper, and brought hope when all else seems to fail?

Our psychiatrists at Serenity Mental Health Centers specialize in administering ketamine therapy for patients struggling with their symptoms. Ketamine therapy is not just a new trend; it's a life-changing breakthrough for people who are struggling with treatment-resistant mental health conditions. This innovative treatment is helping patients regain control of their lives, find peace, and begin to heal where traditional methods have fallen short. Whether you're battling severe depression, navigating the trauma of PTSD, or trying to escape the grip of addiction, ketamine therapy could be the answer you’ve been waiting for.

What is Ketamine Therapy?

Ketamine is a dissociative anesthetic that has been used in medicine for over 50 years. More recently, researchers and psychiatrists have discovered its powerful effects on brain chemistry when administered in lower, controlled doses to treat mental health conditions. We’ve looked at the studies, the data, and the success stories, and as a result have found that ketamine therapy truly offers something special.

Unlike typical antidepressants that target serotonin or dopamine over weeks or months, ketamine acts rapidly on the brain's glutamate system. This process creates immediate changes in mood, cognition, and perception. At Serenity, we’ve seen the results in the thousands of patients we’ve treated over the past several years. The fact is: it works.

Ketamine therapy, also referred to as ketamine infusion therapy or ketamine mental health treatment, involves delivering low doses of ketamine into the bloodstream under the medical supervision of our board-certified psychiatrists. This process allows the brain to reset its patterns and break through the rigid cycles often seen in depression, PTSD, and addiction.

Patients often describe the experience as freeing, like a mental reset that gives them room to breathe and think clearly for the first time in years. We believe ketamine therapy can do the same for you!

How is Ketamine Therapy Administered?

Ketamine therapy is typically administered through intravenous (IV) infusion. This infusion therapy is considered the gold standard of ketamine administration because of its precision, control, and consistent absorption. Each session usually lasts around 40 to 60 minutes, during which patients are monitored closely by trained medical staff.

The treatment takes place in a quiet, comfortable room where patients can relax during the infusion. Some patients report mild dissociation or a floating sensation, but most report a sense of calm and emotional release. Whatever the case, side effects of ketamine therapy usually dissipate within hours or days. The number of sessions varies depending on the individual, but an initial series often includes six infusions over two to three weeks, followed by maintenance treatments as needed.

How Does Ketamine Therapy Help with Depression?

Depression affects the brain on multiple levels, altering everything from mood regulation to neural connectivity. Traditional antidepressants target serotonin and norepinephrine but often take weeks to work, if they work at all. Ketamine for depression is different. It acts on the NMDA receptor, a part of the glutamate system, which is responsible for synaptic plasticity, memory, and learning.

When someone is experiencing depression symptoms, their brain may show reduced neuroplasticity and impaired communication between neurons. Ketamine rapidly increases glutamate activity, promoting the growth of new synapses and restoring functional brain networks. This means that communication improves, and symptoms alleviate. Patients often feel relief within hours of their first treatment.

In clinical trials, ketamine therapy has shown remarkable results. Individuals with treatment-resistant depression who haven’t responded to multiple medications find that ketamine brings clarity, motivation, and emotional balance back into their lives. It's not just about lifting the fog; it's about reshaping how the brain processes pain, sadness, and fear.

How Does Ketamine Therapy Help with PTSD?

Post-Traumatic Stress Disorder, or PTSD, is a complex condition deeply rooted in trauma. It affects how the brain processes memories, threats, and emotions. Many people with PTSD symptoms struggle with flashbacks, nightmares, emotional numbness, and an ongoing sense of fear or hyper-vigilance. These responses are often tied to overactive amygdala activity and disrupted prefrontal cortex function.

Ketamine therapy helps by dampening the overactive neural circuits that keep the brain stuck in fight-or-flight mode. It also enhances communication between the hippocampus (where memories are stored) and the prefrontal cortex (which regulates thought and behavior). This allows traumatic memories to be processed in a more adaptive, less emotionally overwhelming way.

Studies show that ketamine infusion therapy can provide rapid and lasting relief for PTSD, even in individuals who have not responded to traditional medications or therapy. This is especially the case for our patients at Serenity. Patients often describe feeling like their trauma is no longer the central focus of their identity. The emotional charge might still be there, but it's quieter, less invasive, and easier to work through with support from a psychiatrist or therapist.

How Does Ketamine Therapy Help with Addiction?

Addiction is a chronic condition that alters the brain's reward system and decision-making abilities. Whether it involves alcohol, opioids, or other substances, addiction hijacks the brain's dopamine pathways and traps individuals in compulsive behaviors and self-destructive cycles. It's not just a habit; it’s a neurochemical loop that’s incredibly hard to break.

Ketamine has been shown to interrupt this loop by resetting brain activity and enhancing neuroplasticity. More specifically, it reduces cravings and improves impulse control by modulating glutamate and GABA neurotransmitter systems. It also helps address the emotional pain and trauma that often drive substance use in the first place.

Ketamine can be a powerful tool for those looking to break free from addiction. It's especially effective when used in the early stages of recovery, giving patients the mental clarity and emotional stability they need to stay on track. Ketamine mental health treatment has shown promise in helping patients reduce relapse rates and rebuild their lives.

What Can I Expect After a Ketamine Treatment Session?

After a ketamine infusion therapy session, patients often report feeling emotionally lighter, mentally clearer, and more optimistic. Some people notice immediate relief from depression or anxiety, while others see gradual improvements over several treatments. The experience can vary, but the overall trend is toward reduced emotional distress and improved cognitive flexibility.

Mild side effects like dizziness, nausea, or dissociation may occur, but they typically subside shortly after the session. It's important to have a trusted friend or family member available to drive you home, as ketamine can temporarily affect coordination and alertness. Your psychiatrist will monitor your progress and adjust your treatment plan based on your response and overall mental health.

What sets ketamine apart from other interventions is its ability to offer relief when everything else has failed. For many patients, the shift is profound. Patients find that symptoms clear quickly as they begin to rediscover hope, purpose, and a sense of control.

Rapid Relief: Book Your Appointment Today!

If you’re living with severe depression, PTSD, or addiction, you don’t have to keep suffering in silence. Ketamine therapy offers a new way forward that’s rooted in science, compassion, and real, lasting change. With guidance from skilled psychiatrists and the support of local ketamine clinics, you can finally experience the breakthrough you've been waiting for.

At Serenity Mental Health Centers, we believe in personalized care that empowers you to heal. Our team of psychiatrists is trained in ketamine infusion therapy and passionate about helping patients overcome even the most persistent challenges. We work with your history, your symptoms, and your goals to develop a plan that truly works for you.

Whether you’re exploring Ketamine for depression, seeking relief from PTSD, or trying to break free from substance use, we’re here to help. Don’t wait another day. Reach out to one of our local ketamine clinics and discover how Ketamine therapy near you can lead to real, rapid relief.

Request Appointment

*All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.