Ketamine Therapy: Lifting the Weight of PTSD and Suicidal Thoughts

By: Tanner Manwaring, DNP

5/8/2025

Living with post-traumatic stress disorder (PTSD) can feel like you’re trapped in a cycle you can’t escape. For many people, especially those struggling with complex PTSD (C-PTSD), this condition becomes more than a daily challenge; it can become unbearable. Suicidal thoughts, self-harm, and hopelessness often take root when traditional treatment options don’t work. If that’s where you are, know you’re not alone and that you aren’t beyond help.

Our team at Serenity Mental Health Centers understands how consuming PTSD symptoms can be. That’s why we offer advanced psychiatric care, including ketamine therapy, for those who haven’t found relief through traditional methods. Whether you’ve tried counseling, medications, or other methods with no results, ketamine therapy may be the breakthrough that finally provides the relief you deserve.

What Is PTSD?

PTSD is a mental health condition that develops after exposure to trauma. It can result from a single traumatic event or years of repeated emotional or physical harm. Symptoms vary, but typically include:

  • Flashbacks or intrusive memories
  • Nightmares or insomnia
  • Avoidance of people, places, or reminders of trauma
  • Hypervigilance or a constant state of fear
  • Emotional numbness
  • Self-isolation or withdrawal
  • Suicidal ideation or self-harm

In cases of complex PTSD, the trauma is often long-term and deeply rooted, causing emotional dysregulation, chronic shame, and a sense of disconnection from others. This condition is deeply painful and extremely difficult to treat using conventional methods alone.

What Is Ketamine Therapy?

Ketamine therapy is a practice in which a dissociative anesthetic is administered via IV to rewire areas of the brain affected by severe mental health conditions. In recent years, it has been recognized for its powerful effects on mental health, especially when traditional antidepressants have failed. Ketamine infusions are administered in low doses and act on the glutamate system, which is a critical part of the brain’s mood regulation network.

It's also important to note that ketamine is not an opioid. It does not create the same risk of dependency and works through entirely different pathways. While some people mistakenly associate ketamine with recreational misuse, medical ketamine therapy is carefully administered and backed by a growing body of research and clinical trials.

How Ketamine Helps Heal Trauma

PTSD changes how the brain functions. The amygdala becomes overactive, keeping the brain stuck in a constant fight-or-flight state. The prefrontal cortex, which helps regulate logic and decision-making, becomes suppressed as well. Ketamine therapy helps reverse these imbalances. It promotes neuroplasticity, which rewires how the brain processes memory, fear, and emotion.

Patients often describe ketamine therapy as a mental reset. For many, suicidal ideation begins to fade after just one or two sessions. Others report a feeling of peace they haven’t known in years. It doesn’t erase trauma, but it gives the brain a chance to heal from it.

Why Traditional Treatments Often Fall Short

While antidepressants and counseling have been effective for some patients with PTSD, they often fall short in severe or treatment-resistant cases. Many patients:

  • Don’t respond to SSRIs or mood stabilizers
  • Struggle with intolerable side effects from medications
  • Can’t engage meaningfully in therapy due to overwhelming symptoms
  • Experience years of trial and error without progress

For those patients, ketamine therapy offers fast, powerful relief when nothing else has worked.

What to Expect During Ketamine Infusion Therapy

At Serenity, ketamine treatments are conducted in a comfortable outpatient setting. Each session lasts about 45 to 60 minutes. You'll be monitored by our care team throughout your infusion in a quiet and calming environment designed to help you feel safe.

We also encourage ketamine assisted psychotherapy, which combines the neuroplastic effects of ketamine with structured gratitude therapy. This method helps patients explore painful memories or thoughts while their brain is more flexible and less guarded.

How Many Ketamine Treatments Will I Need?

Treatment varies by patient, but most individuals begin with a series of six infusions spread out over two to three weeks. This initial phase is designed to “reboot” the brain’s emotional circuitry. Afterward, maintenance sessions may be scheduled as needed based on how your symptoms respond.

Common Ketamine Therapy Side Effects

Most side effects of ketamine therapy are short-lived and mild. These may include:

  • Lightheadedness or dizziness during the infusion
  • Mild dissociation (feeling detached from your body or surroundings)
  • Nausea or dry mouth
  • Fatigue or grogginess afterward

These effects usually wear off within an hour or two post-treatment. Long-term side effects of ketamine treatment are rare, especially when infusions are done under medical supervision with proper monitoring and dosage.

Debunking Common Myths About Ketamine

It’s important to clear up misconceptions:

  • Myth: Ketamine is addictive.
    Fact: In clinical settings, ketamine is not habit-forming and is carefully monitored.
  • Myth: Ketamine is only for pain.
    Fact: While ketamine does treat pain, it has profound mental health benefits, especially for treatment-resistant conditions like PTSD.
  • Myth: It’s a last resort.
    Fact: Ketamine therapy can be introduced early in cases where standard treatment has failed or where symptoms are severe.

Why Choose Serenity for Ketamine Treatment?

At Serenity, your care is led by experienced, board-certified psychiatrists who specialize in trauma-informed treatment. We offer more than a procedure; we provide a path toward recovery that’s tailored to you. Whether you’ve just begun your journey or you’ve been living with PTSD for years, our team is here to guide you with compassion, expertise, and care.

We combine adult psychiatry, general psychiatry, and outpatient counseling with advanced treatments like ketamine infusion therapy. For those wondering, “Is there a ketamine treatment near me?” the answer is yes. Serenity has clinics across the country where we happily provide affordable access to local psychiatrists, offering world-class care right in your community.

Don’t Wait to Find Relief

You may feel like no one understands what you’re going through, and you may be exhausted by the cycle of trial and error, medications that don’t help, and a sense of deep, persistent fear. But you are not alone, and you are worth fighting for.

At Serenity, we see patients every day who feel like they are out of options. PTSD is a heavy burden, but it is not a life sentence. You deserve to live without constant fear or the weight of suicidal thoughts. We’re here to help you get there.

If you're ready to take the next step toward relief, book your consultation today and let our team of psychiatrists walk this journey with you.

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*All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.